The International Conference on Information and Knowledge Systems (ICIKS 2021) aims to gather both researchers and practitioners in the fields of Information Systems, Artificial Intelligence, Knowledge Management and Decision Support. ICIKS seeks to promote discussions on various organizational, technological, and socio-cultural aspects of research in the design and use of information and knowledge systems in organizations. Considering the large amount of data, information, and knowledge created and used in the organizations, especially with the evolution of information and communications technology platforms, organizations under the process of digital transformation constantly search for innovative concepts and creative applications. More importantly, ICIKS aims beyond the predominant role of technologies, seeking discussions on the essential interactions between individuals, who are the ultimate technology users. Organizations must be aware of the importance of data, information, human being behavior, and knowledge owned by their members. Creating activities to enhance identification, preservation, and use of this knowledge is a powerful means to improve the level of the organizations’ performances. Thus, organizations must invest on human interactions. Since COVID-19 crisis, more and more of these interactions are made through digital information systems which enhance knowledge sharing and cooperation culture. This will insure better information and knowledge creation, transfer and preservation taking into account the security of socio-technical systems. We encourage submission of research related to the design, implementation, and use of information and knowledge systems that take into consideration the cultural context of the organizations, and the viewpoints of their shareholders. Researchers and practitioners are invited to share recent advances in methodologies, models and tools concerning decision processes and information and knowledge systems that contribute to the success of digital transformation in organizations.